Hypertensive Disorders of Pregnancy leads to Neurodevelopmen
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Hypertensive disorders of pregnancy (HDP) have been associated with poorer neurodevelopmental outcomes in offspring.

A Study was conducted to investigate the associations of maternal HDP with risks in offspring of autism spectrum disorders (ASDs), attention-deficit/hyperactivity disorder (ADHD), and intellectual disability (ID), as well as variation in overall cognitive performance in offspring.

This Swedish register-based study used data from a birth cohort divided into 1085024 individuals born between 1987 and 1996 and followed up until December 31, 2014, and 285901 men born between 1982 and 1992 who attended assessments for military conscription, including a cognitive function test.

Results:
--The prevalence of maternal HDP was 4.0% in the 1987-1996 birth cohort and 5.1% in the military conscription cohort.

--A total of 15858 participants received a diagnosis of ASD, 36852 received a diagnosis of ADHD, and 8454 received a diagnosis of ID.

--The mean (SD) cognitive score among the men in the conscription cohort was 5.1.

--In whole-cohort analysis with multivariable adjustment, HDP were associated with offspring ASDs (hazard ratio [HR], 1.22), ADHD (HR, 1.10), and ID (HR, 1.39).

--Analysis comparing siblings discordant for HDP were less statistically powered but indicated estimates of similar magnitude for ASDs (HR, 1.19) and possibly ADHD (HR, 1.09), but not for ID (HR, 1.04).

--Hypertensive disorders of pregnancy were associated with somewhat lower cognitive scores in whole-cohort analysis, but in within-sibship analysis, the association was null.

According to the findings, HDP is linked to a minor increase in the incidence of ASDs and probably ADHD in offspring, while correlations with ID and cognitive performance are likely confounded by mutual parental (environmental or genetic) influences.

Source: https://jamanetwork.com/journals/jamapediatrics/fullarticle/2777593
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