Hypoglycemia fear, family conflict influence HbA1c trends in
Parent-reported hypoglycemia fear and diabetes-specific family conflict may predict HbA1c trajectories for children aged 5 to 9 years with recent-onset type 1 diabetes, according to findings published in Diabetic Medicine.

This study aimed to explore glycated haemoglobin (HbA1c) patterns in 5- to 9-year-olds in the recent-onset period of type 1 diabetes and identify parent psychosocial factors that may predict children's HbA1c trajectory using a prospective, longitudinal design.

Researchers measured family demographics and parent psychosocial factors at baseline. We collected HbA1c levels from children every 3 months for up to 30 months. Deriving several features around HbA1c trends, we used k-means clustering to group trajectories and linear and logistic regressions to identify parent psychosocial predictors of children's HbA1c trajectories.

Results:
-- The final cohort included 106 families (48 boys, mean child age 7.50 ± 1.35 years and mean diabetes duration 4.71 ± 3.19 months).

-- Researchers identified four unique HbA1c trajectories in children: high increasing, high stable, intermediate increasing and low stable.

-- Compared to a low stable trajectory, increasing parent-reported hypoglycaemia fear total score was associated with decreased odds of having a high stable or intermediate increasing trajectory.

-- Increasing parent-reported diabetes-specific family conflict total score was associated with increased odds of having a high stable or intermediate increasing trajectory.

Conclusively, this study is the first to identify distinct HbA1c trajectories in 5- to 9-year-olds with recent-onset type 1 diabetes as well as parent psychosocial factors that may predict high stable or increasing trajectories and could represent future treatment targets.

Source: https://onlinelibrary.wiley.com/doi/abs/10.1111/dme.14637
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