Hypothermic Machine Perfusion in Liver Transplantation
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Transplantation of livers obtained from donors after circulatory death is associated with an increased risk of nonanastomotic biliary strictures. Hypothermic oxygenated machine perfusion of livers may reduce the incidence of biliary complications.

In this multicenter, controlled trial, we randomly assigned patients who were undergoing transplantation of a liver obtained from a donor after circulatory death to receive that liver either after hypothermic oxygenated machine perfusion (machine-perfusion group) or after conventional static cold storage alone (control group). The primary endpoint was the incidence of nonanastomotic biliary strictures within 6 months after transplantation. Secondary endpoints included other graft-related and general complications.

A total of 160 patients were enrolled, of whom 78 received a machine-perfused liver and 78 received a liver after static cold storage only.

--Nonanastomotic biliary strictures occurred in 6% of the patients in the machine-perfusion group and in 18% of those in the control group.

--Postreperfusion syndrome occurred in 12% of the recipients of a machine-perfused liver and in 27% of those in the control group.

--Early allograft dysfunction occurred in 26% of the machine-perfused livers, as compared with 40% of control livers.

--The cumulative number of treatments for nonanastomotic biliary strictures was lower by a factor of almost 4 after machine perfusion, as compared with control.

--The incidence of adverse events was similar in the two groups.

Conclusively, hypothermic oxygenated machine perfusion led to a lower risk of nonanastomotic biliary strictures following the transplantation of livers obtained from donors after circulatory death than conventional static cold storage.

Source: https://www.nejm.org/doi/full/10.1056/NEJMoa2031532
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