Hypothyroidism more prevalent during late perimenopause, pos
The prevalence of hypothyroidism — overt and subclinical — is higher among women during the late menopause transition and postmenopause compared with premenopause. Accumulated data on menopausal transition suggest that the late menopausal transition stage, among other stages, seems to be the most critical period during which various menopausal symptoms and measurable physiologic changes are likely to manifest.

Data from 53,230 women aged 40 years or older (mean age, 47.1 years) who participated in the Kangbuk Samsung Health Study at the Kangbuk Samsung Hospital Total Healthcare Center in Seoul and Suwon, South Korea, and had a health examination performed between 2014 and 2018. The Stages of Reproductive Aging Workshop + 10 criteria were used to determine menopausal stages. Electroluminescence immunoassays were conducted to measure serum thyroid-stimulating hormone, free thyroxine and free triiodothyronine levels.

Free T3 and TSH levels were highest in the study cohort during postmenopause. Free T4 levels were similar between premenopause and postmenopause.

In multivariable-adjusted analysis, the prevalence of overt hypothyroidism was higher in late perimenopause and postmenopause compared with premenopause (P = .002). Similarly, the prevalence of subclinical hypothyroidism was higher during late perimenopause and postmenopause compared with premenopause (P = .001). No increased prevalence in overt and subclinical hyperthyroidism was observed during the different menopausal stages.

Source: https://www.healio.com/news/endocrinology/20220406/hypothyroidism-more-prevalent-during-late-perimenopause-postmenopause