ICMR Study Provides a New Definition For SARS-CoV-2 Re-infec
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Two positive tests at an interval of at least 102 days with one interim negative test have been defined as SARS-CoV-2 re-infection for establishing surveillance systems, according to an ICMR study. But a confirmation of the re-infection will require a whole genome sequencing, it stated. An investigation was conducted with the objective to develop an epidemiological case definition of possible SARS CoV-2 re-infection and assess its magnitude in India.

Re-infection with SARS CoV-2 was defined as two positive tests at an interval of at least 102 days with one interim negative test. During the archive based, telephonic survey, thirty-eight of the 58 eligible patients could be contacted, with twelve (31.6%) being healthcare workers. Majority of the participants were asymptomatic.

"To conclude, a working epidemiological case definition of SARS CoV-2 re-infection is important to strengthen surveillance. The present investigation contributes to this goal and records reinfection in 4.5% of SARS CoV-2 infected individuals in India," the paper stated.

"SARS CoV-2 re-infection is still a rare phenomenon, the study says. It says there is a need for an epidemiological definition of re- Infection for establishing surveillance systems. "This study contributes to such goal," it says. Some respondents in the study had a symptomatic second episode as opposed to the first one. The rate and duration of hospitalization were not compared. During the initial phase of the pandemic in India, all cases were being hospitalized for at least 14 days.

"It is not logistically feasible to store the samples of millions of positive cases for future sequencing to identify an important phenomenon like SARS CoV-2 re-infection," the study said. Both CDC and European CDC suggested the use of genomic evidence for confirmation of reinfection, However, an epidemiological working definition will be more pragmatic and helpful to assess the magnitude of re-infection in most population and resource-constrained settings.

Source:
https://www.cambridge.org/core/journals/epidemiology-and-infection/article/sarscov2-reinfection-development-of-an-epidemiological-definition-from-india/2140E6F272E50BD8613776BCCC047447
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