IIIT Delhi develops AI model to repurpose existing drugs to
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Indraprastha Institute of Information Technology (IIIT-Delhi) on 12 July said it has developed an Artificial Intelligence (AI) model for drug repositioning in the treatment of Covid-19.

Some well-known examples of repositioned drugs are Hydroxychloroquine (HCQ), Dexamethasone, Remdesivir, Avifavir/Favipiravir etc. Some lesser-known drugs that are on trial include Ribavirin, Umifenovir, Sofosbuvir and several antiretrovirals.

• The database of drugs (drugbank.ca) lists more than 100 approved antivirals. Trying out all of them in clinical trials is not possible.

• "Therefore, we propose to use AI to prune this massive database and select a handful (5 to 10) of drugs that have better chances of succeeding," IIIT Delhi said in a statement.

• In simple terms, the AI model computes the similarity between the chemical structures of the drugs and the genomic structures of existing viruses and the novel Coronavirus.

• The model then looks at the historical information about the efficacy of the drugs on different viruses; it selects similar drugs that have been successful in treating viruses that have a genomic structure close to that of the novel Coronavirus.

• The AI model that could prove to be an indispensable tool in the battle against Covid-19 has been the result of a collaboration between IIIT Delhi, IPGME&R Kolkata and INRIA, Saclay, Paris, France.

Source: https://health.economictimes.indiatimes.com/news/medical-devices/iiit-delhi-develops-ai-model-to-repurpose-existing-drugs-to-treat-covid-19/76939010
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