IUD Cuts Heavy Menses in Nulliparous Patients With Obesity
New phase 3 data support the use of the levonorgestrel 52 mg intrauterine device (IUD) in nulliparous women with obesity and heavy menstrual bleeding. They showed a 97% reduction in blood loss 6 months after placement of the device, which is sold as the contraceptive Liletta. They provided treatment with Liletta to 105 individuals with proven heavy menstrual bleeding. The patients' median blood loss during two menses prior to placement of the device was 165 mL (range, 73-520 mL).

Participant demographics were: 65% White, 24% Black, 10% Hispanic, 4% Asian, and 7% who identified with other racial groups. Mean body mass index (BMI) was 30.9, and 45% of individuals met the criteria for obesity (BMI > 30), including 13% who had a BMI 40. Nearly 30% of participants in the study had never given birth and none had known medical, anatomic, infectious, or neoplastic causes of bleeding. Among the 23% of participants who did not complete the study, 4% experienced expulsions of the device, which Creinin said is a rate twice as high as that seen in women using hormone-releasing IUDs for contraception.

Source: https://www.medscape.com/viewarticle/973464?src=rss