IV Oxygen therapy
Oxygen is delivered through lungs. In ARDS, as lungs are stiff, despite high flow oxygen even through ventilator, oxygen is not delivered to capillaries. Giving Oxygen IV directly is challenging as it can produce bubbles and embolism.

Researchers from Harvard Medical School and Boston Children's Hospital developed liquid oxygen and covered oxygen bubbles by lipid membrane which prevents them from merging with each other. Infused liquid oxygen through a series of sequential nozzles of decreasing size and able to create bubbles of oxygen those are smaller than a single RBC.

Researchers tested their machine on human donor blood and in rats and found it passed as a proof of concept. In human blood, their machine could increase blood oxygen saturation from 15% to over 95% within seconds to minutes. Not yet ready for testing in humans. They plan to continue with tests on larger animals before testing on humans.

Source: https://www.pnas.org/doi/full/10.1073/pnas.2115276119
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