Imaging Biomarkers of Hepatic Fibrosis
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Researchers suggest that hepatic periportal space widening is reliable for the diagnosis of Hepatic Fibrosis.

The purpose of this article published by the American Journal of Roentgenology was to assess the reliability and accuracy of hepatic periportal space widening and other qualitative imaging features for the prediction of hepatic fibrosis.

This single-center retrospective study identified consecutive patients who had undergone liver MR elastography. Two abdominal radiologists independently reviewed anatomic images, assessing multiple qualitative features of chronic liver disease (CLD) including periportal space widening. Each reader also measured the periportal space at the main portal vein (MPV) and right portal vein (RPV). Sensitivity and specificity were determined for the detection of any hepatic fibrosis (stage I or higher) and of advanced fibrosis (stage III or higher) using stiffness on MR elastography as the reference standard.

Of 229 subjects, 157 had fibrosis and 78 had advanced fibrosis.

--Agreement for periportal space widening was moderate, and agreement for remaining features was moderate to substantial.

--Agreement for the periportal space at the MPV was moderate, and agreement for the periportal space at the RPV was near perfect.

--Periportal space widening had the highest sensitivity for any fibrosis, with limited specificity.

--Surface nodularity had the highest specificity for any fibrosis, with limited sensitivity.

--Periportal space widening plus one or more additional imaging features of CLD or the presence of surface nodularity alone had a sensitivity of 72.6% and specificity of 76.1%.

--A periportal space at the MPV greater than 9.5 mm had a substantial agreement with qualitative periportal space widening.

Conclusively, periportal space widening has a high sensitivity for hepatic fibrosis, with moderate specificity when combined with additional anatomic features of CLD.

Source: https://www.ajronline.org/doi/abs/10.2214/AJR.20.23099
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