Immune and clotting components in blood could contribute to
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A scientific review has found evidence that a disruption in blood clotting and the first line immune system could be contributing factors in the development of psychosis.

Recent studies have identified blood proteins involved in the innate immune system and blood clotting networks as key players implicated in psychosis.

The researchers analyzed these studies and developed a new theory that proposes the imbalance of both of these systems leads to inflammation, which in turn contributes to the development of psychosis.

The work proposes that alterations in immune defense mechanisms—including blood clotting—lead to an increased risk of inflammation, which is thought to contribute to the development of psychosis.

The new theory further refines the prevailing 'two-hit' hypothesis, where early genetic and/or environmental factors disrupt the developing central nervous system and increases the vulnerability of the individual to subsequent, late environmental disruptions.

"Early identification and treatment significantly improve clinical outcomes of psychotic disorders. Our theory may provide a further step to biomarkers of psychosis and allow the identification of therapeutic targets for early and more effective treatment," said the author.

Molecular Psychiatry
Source: https://doi.org/10.1038/s41380-021-01197-9
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