Immunotherapy An Ideal Mode Of Treatment For Advanced Stage
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India is currently experiencing a devastating wave of Covid-19 with second-highest number of confirmed cases in the world. Stronger immune system and immunity has made its presence felt exceedingly more during this pandemic. SARS-CoV-2 is highly replicative and poorly immunogenic, failing to trigger a type I IFN response and TH1 chemokine release.

Age, underlying comorbid conditions like chronic kidney disease (CKD), chronic obstructive airway disease (COAD), obesity, hypertension, a pre-existing or ongoing cancer treatment in affected persons are some of the factors affecting severity of SARS CoV-2 infection.

~ Covid-19 and Cancer care

Due to restrictions put on travel, delays in regular follow ups, postponement of scheduled surgeries, unavailability of palliative care resources, halting of cancer screening programs and in general fear among people to visit hospitals have all contributed to greater number of cancer patients progressing to and being diagnosed in advanced stages.

Chemotherapies may induce cellular senescence in normal tissues, thereby promoting local and systemic inflammation causing debilitating effects. Radiation-induced pulmonary fibrosis (RIPF) can lead to irreversible destruction of lung architecture and disruption of gas exchange. Cytokine storm is an overaggressive Immune response phenomenon that is the most severe consequence of Covid-19 infection damaging lung and other tissues.

~ Cancer Regimen in COVID 19 era: What’s in store?

Years of research has established that cancer is an extremely heterogeneous disease. Every cancer is different, as is every patient battling the condition. We see differences not only between cancer cells from different patients, but also between cancer cells within the same patient. We need to adopt a multi-disciplinary approach to cancer care, customize it to each cancer and, finally, for each patient.

~ Immunity and its unleashed potential

One of the weapons that help most in the fight against coronavirus disease is our immunity. A strong immune system will fight off any disease with more ease as compared to a weak one which is more prone to falling prey to it. Many combinatorial approaches using chemotherapy and immunotherapy are also being employed as they have shown significant outcomes. The challenge is to identify the most effective, minimally toxic treatment, for each cancer patient especially now in the Pandemic era.