Impact of Adherence to Oral Acyclovir Prophylaxis in the Rec
A Study was conducted to evaluate the long-term role of adherence to oral acyclovir prophylaxis in reducing the risk for recurrent herpes simplex virus keratitis (HSK) in children.

A retrospective cohort study was performed including all pediatric patients 16 years or younger with their first HSK diagnosis and treatment. Children were started on a standardized oral acyclovir prophylactic regimen after the acute phase. Adherence to prophylaxis was assessed monthly through parent interviews. The possible association between any recurrence (not only the first) and exposure to acyclovir prophylaxis was evaluated using random-effects multivariate logistic regression.

--A total of 20 eyes of 17 patients (8 boys and 9 girls) were included. The mean follow-up time was 3.5 years.

--Adherence to acyclovir prophylaxis was registered in 100% of patients with no recurrences and in 36.4% of patients with 1 or more recurrences.

--All other tested variables did not differ between the 2 groups. The multivariate model confirmed the lower risk for recurrence in patients who were compliant to therapy.

--No adverse effects were recorded during follow-up.

To summarize, oral acyclovir prophylaxis is a safe and effective medical treatment for recurrent HSK, and its long-term efficacy is linked to therapeutic compliance.