Impact of Disease Activity on 5 year Outcomes in patients un
A Study was conducted to assess the impact of disease activity on clinical outcomes in a real-world cohort with neovascular age related macular degeneration (nAMD) over 5 years.

Data were obtained from the prospectively-defined Fight Retinal Blindness registry. Eyes were divided into tertiles based on the proportion of visits where choroidal neovascular lesion was active (low, moderate and high) up until 5 years.

Results:
--The adjusted mean VA change was -0.5 letters (-1.8, 1.1), 1.8 letters (0.2, 3.4) and -2.5 letters (-4.2, -1.3) in the low, moderate and high activity groups respectively.

--Eyes in the low activity group were more likely to develop macular atrophy (56%, 47% and 26% in the low, moderate and high activity groups respectively) but less likely to develop subretinal fibrosis (27%, 35% and 42% in the low, moderate and high activity groups respectively).

In conclusion, eyes with higher and lower levels of disease activity had worse outcomes after 5 years than eyes with moderate activity, owing to the development of subretinal fibrosis or macular atrophy.

Source: https://journals.lww.com/retinajournal/Abstract/9000/The_Impact_of_Disease_Activity_on_5_year_Outcomes.95437.aspx
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