Impact of Preoperative Occult-Bacterial Translocation on Sur
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Occult-bacterial translocation (O-BT) has been reported as the condition in which microorganisms are detected in blood or lymph nodes by a highly sensitive method. Along with the other risk factors O-BT is also associated with surgical site infection post pancreatoduodenectomy.

A prospective observational study with patients undergoing pancreatoduodenectomy for periampullary diseases was conducted. Blood samples were collected immediately after induction of anesthesia. The status of O-BT was investigated using bacterium-specific ribosomal RNA-targeted reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR). The impact of O-BT on surgical site infection (SSI) was analyzed.

A total of 155 patients were included.

--The positive rate in preoperative blood samples detected by RT-qPCR was significantly higher than that obtained by the culture method.

--Preoperative blood samples were contaminated with 1.0 to 19.2 bacterial cells/mL in positive patients, and 30 of the 41 detected microorganisms were obligate anaerobes.

--No differences in preoperative factors were observed between patients with positive and negative RT-qPCR results.

--The incidence of any SSI was significantly higher in patients with contaminated preoperative blood than in other patients.

--Multivariable analysis indicated that contaminated preoperative blood was identified as one of the independent risk factors for SSI.

Journal of the American College of the Surgeons
Source: https://doi.org/10.1016/j.jamcollsurg.2020.12.001
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