Impact of Vitamin A in Children Hospitalized for Measles in
Vitamin A supplement for severe measles that require hospitalization is recommended by world medical authorities. A national vitamin A deficiency reported in conjunction with an outbreak of measles in Italy has provided a chance to assess the efficacy of vitamin A in a high-income environment with an uneven allocation.

Researchers conducted a prospective controlled cohort study involving children admitted for measles to a tertiary-care hospital in Southern Italy. The primary outcome was the duration of fever. Secondary outcomes included the length of hospitalization, rate of complications, need for antibiotic treatment and body temperature.

--A total of 108 inpatient children were enrolled; 36 received 2 doses of oil-based vitamin A according to age, and 72 matched controls received standard care.

--There were no significant differences between the study groups in the duration of fever, length of hospitalization, maximum body temperature, rate of organ and hematologic complications or need for antibiotic treatment.

--Overall, vitamin A supplementation did not reduce the risk of any complications (relative risk, 1.33).

Conclusively, Vitamin A does not change the clinical course of measles infection or the rate of complications in children hospitalized in a high-income country.