Impact of arterial stiffness on all-cause mortality in patie
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Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in COVID-19 patients. Hypertension (HT) and age are the two principal determinants of arterial stiffness (AS). This study aimed to estimate AS in COVID-19 patients requiring hospitalization and analyze its association with all-cause in-hospital mortality.

This observational, retrospective, multicenter cohort-study analyzed 12,170 patients admitted to 150 Spanish centers included in the SEMI-COVID-19 Network. Researchers compared AS, defined as pulse pressure {greater than or equal to} 60 mmHg, and clinical characteristics between survivors and nonsurvivors. Mean age was 67.5 {plus minus} 16.1 years and 42.5% were women.

Overall, 2,606 (21.4%) subjects died. Admission systolic blood pressure (SBP)<120 and {greater than or equal to} 140 mmHg was a predictor of higher all-cause mortality (23.5% and 22.8%, respectively), compared to BP =120-140 mmHg (18.6%).

The 4,379 patients with AS (36.0%) were older and had higher systolic and lower diastolic BP. Multivariate analysis showed that AS and SBP < 120 mmHg significantly and independently predicted all-cause in-hospital mortality after adjusting for sex, age tertiles, Charlson Comorbidity Index, heart failure, and previous and in-hospital antihypertensive treatment.

This data show that AS and admission SBP<120 mmHg had independent prognostic value for all-cause mortality in COVID-19 patients requiring hospitalization.