Impact of rapid enterovirus PCR testing on the management of
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Diagnostic evaluation of febrile young infants is challenging. Empirical antimicrobial treatment is therefore common practice in this setting despite a high percentage of causative viral infections. The objective of this study was to investigate the impact of rapid enterovirus cerebrospinal fluid polymerase chain reaction (CSF EV PCR) test on hospital length of stay (LOS) and antimicrobial treatment duration in young febrile infants.

The use of rapid CSF EV PCR testing in febrile infants < 90 days of age undergoing full sepsis evaluation leads to a significant reduction of antimicrobial treatment duration and hospital LOS in EV positive compared to negative patients but also to an overall reduction of antimicrobial treatment in patients with aseptic meningitis. These benefits of rapid CSF EV PCR testing in febrile neonates and infants on the duration of treatment and hospital stay may be increased if systematic testing is introduced (e.g. testing all febrile infants < 90 days of age who undergo lumbar puncture during enteroviral season independently of pleocytosis), time to reporting of the test result is optimized, and medical staff is instructed to rapidly implement the positive test result on patient management.

Source:https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-020-02066-0
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