Impaired Bone Health in Children With Biliary Atresia
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The aim of the study was to examine the frequency of rickets and bone fractures and to assess areal bone mineral density (aBMD) in childhood among patients with biliary atresia (BA).

Researchers gathered data on all patients diagnosed with BA that survived more than 1 year of age. Data on gestational age, birth weight, postsurgical medications, and history of rickets and bone fractures were collected retrospectively. Serum levels of 25-hydroxyvitamin D [25(OH)D] postportoenterostomy (PE) were collected. Plain radiographs and dual energy X-ray absorptiometry (DXA) measurements of study subjects were reviewed.

Out of 49 patients, 7 were diagnosed with rickets during infancy. Clearance of jaundice [odds ratio 0.055] was a protective factor against rickets. Sufficient 25(OH)D levels were reached 3 months post-PE. Eleven patients suffered at least one bone fracture (range 1–9) during childhood and adolescence. In DXA measurements, median lumbar spine aBMD anthropometrically adjusted z-scores were as follows: in native liver survivors 0.8 (interquartile range [IQR] 1.9 to 1.4) at 5 and 0.3 (IQR 1.3 to 0.8) at 10 years and for liver transplanted patients 0.4 (IQR 0.2 to 1.1) at 5 and 0.6 (IQR 0.1 to 1.3) at 10 years.

BA patients have an increased risk for rickets and bone fractures compared with the normal population. Most BA patients have aBMD within normal range between 5 and 10 years of age irrespective of liver transplantation status.

Source: https://journals.lww.com/jpgn/Abstract/2020/12000/Impaired_Bone_Health_in_Children_With_Biliary.5.aspx
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