Implantable collamer lens V4c implantation in patients with
A Study was conducted to investigate the long-term safety and efficacy of implantable collamer lens (ICL) V4c implantation and changes in the anterior lens density (ALD) in patients with myopia more than 40 years of age.

This prospective study included 104 eyes of 52 patients more than 40 years of age before ICL V4c implantation. Spherical equivalent (SE), uncorrected distance visual acuity, corrected distance visual acuity (CDVA), intraocular pressure, endothelial cell density, anterior chamber depth, anterior chamber volume and anterior chamber angle preoperatively, at 1 and 3 months, and at 3 years postoperatively were recorded. Pentacam HR was used to analyse ALD changes at a depth of 0.5, 1.0 and 1.5?mm within a 3?mm diameter range around the pupil’s centre.

--The overall follow-up was uneventful at 42±7.1 months; the safety index at last follow-up was 1.26±0.35 and the efficacy index was 0.91±0.41.

--No eye lost the Snellen line of CDVA, 76% of the eyes had an increase in CDVA for more than 1?line and 62% had an SE within ±0.50 dioptre.

--The increase in ALD at 0.5, 1 and 1.5?mm was 16.52%±10.46%, 16.72%±9.85% and 17.28%±11.93%, respectively.

--Preoperative, 1-month and 3-month postoperative ALDs showed correlations with SE and age, and ALD at last follow-up was correlated only with age. There was no correlation between ALD and any other parameters.

In short, in adults over 40 years of age, ICL V4c indicates long term safety and efficacy. In these patients, ALD increased that can be associated with age and SE.