Importance of Vitamin D and E levels at birth with Bronchopu
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Despite advances in neonatal treatment, bronchopulmonary dysplasia (BPD) remains the most prevalent respiratory disease among premature babies. The link between vitamin D/E levels in the blood and BPD in premature infants is still unclear.

Preterm infants were recruited as the research subjects. On the basis of the inclusion and exclusion criteria, a total of 133 eligible cases were finally included. A total of 63 preterm infants with a clear diagnosis of BPD and 5 preterm infants who died before the diagnosis of BPD were in the case group, and 65 non-BPD preterm infants with equivalent baseline characteristics were in the control group.

The BPD group included 38 cases in Grade 1, 18 cases in Grade 2, and 12 cases in Grade 3. The contents of vitamin D and E in the cord blood of different groups were detected by high-performance liquid chromatography and enzyme-linked immunosorbent assay. Correlation analysis adopted the Pearson correlation analytic method.

Results:
--The serum vitamin D and E levels at birth were remarkably lower in the BPD group than the non-BPD group, both of which were also correlated with the severity of BPD.

--The vitamin D and E contents were negatively correlated with the oxygen support duration required for premature infants with BPD.

Finally, this research contributes to understand BPD pathogenesis by demonstrating a connection between vitamin D/E deficiency and BPD severity, implying that vitamin D and E may have therapeutic importance in the prognosis and treatment of BPD.

Source: https://onlinelibrary.wiley.com/doi/10.1002/ppul.25414?af=R
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