In a leiomyoma/ fibroid, which receptor density is greater?
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Archana Venugopal
In a leiomyoma/ fibroid, which receptor density is greater? Estrogen or progesterone? I read in William's Gynaecology textbook that estrogen and progesterone receptor density is greater and that 'Leiomyoma growth are controlled by progesterone directly and in a permissive role by estrogen. ' Please explain. Thank you.
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Dr. D●●●●i S●●h
Dr. D●●●●i S●●h General Medicine
In addition to estrogen and aromatase, there is accumulating evidence that progesterone plays a critical role in uterine fibroid expansion and is essential for estrogen-related fibroid growth. Progesterone acts through two isoforms of PR, PR-A and PR-B, both of which exhibit higher expression in fibroids compared with adjacent myometrium. Similar to ER, relatively little is known about the specific roles and interplay of PR-A and PR-B in fibroids. For more refer to : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734398/... Read more
May 1, 2020Like2
A●●●●●a V●●●●●●●l
A●●●●●a V●●●●●●●l General Medicine
Thank you
May 2, 2020Like