Incidence & Risk factors of Choroidal Neovascularizaion Seco
A Study was conducted to investigate the incidence, risk factors, and clinical outcomes of complicated choroidal neovascularization (CNV) after reduced-fluence photodynamic therapy (PDT) for central serous chorioretinopathy.

This is a retrospective consecutive interventional study including 559 eyes from 520 patients treated by reduced-fluence PDT for central serous chorioretinopathy. The incidence of complicated CNV within 3 months after PDT was calculated. Baseline demographics and ocular findings were investigated to identify risk factors. The clinical course of complicated CNV was analyzed.

--7 cases experienced development of active CNV after PDT within 3 months with a median interval of 4 weeks (range, 2–12 weeks).

--The incidence was estimated as 1.25%. Complicated CNV developed in 6 among 138 eyes with flat irregular pigment epithelial detachment and in 1 among 421 eyes without flat irregular pigment epithelial detachment.

--The median best-corrected visual acuity recovered from 20/100 at the time of CNV development to 20/20 after anti–vascular endothelial growth factor injections (median, 3 times).

Finally, CNV can be adequately controlled with anti–vascular endothelial growth factor injection and may complicate reduced-fluence PDT for central serous chorioretinopathy in about 1% of cases. Following PDT, flat uneven pigment epithelial detachment increases the chance of subsequent CNV.