Incidental Leydig cell tumor in patient with hormone resista
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Leydig cells are located in the testicular interstitial tissue and exhibit the main endogenous secretory activity of male hormones and other nonsteroidal substances. Their activity is controlled by the pituitary gonadotrophin hormone GHRH. It is known that prostate cancer growth is linked to androgens like testosterone or dihydrotestosterone.We hereby present the case of a 55 years old patient with clinical diagnosis of high-risk prostate cancer T2bN1Mo Gleason 9 (4 + 5) treated with androgen deprivation therapy and external beam radiotherapy. Despite treatment, castration levels were not achieved and clinical progression was evidenced by the appearance of bone metastases and progression of PSA. After several hormonal treatments without any PSA or testosterone response, surgical castration was performed by bilateral orchiectomy. The pathology results showed an incidental Leydig cell tumor in the right testicle...

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