Increased incidence of Dyslipidemia, Insulin Resistance in B
A recently published study in the Journal of Mid-Life Health suggests that dyslipidemia and disturbed glucose metabolism are correlated with breast cancer (BC) and supports the hypothesis that total cholesterol, LDL-C, and TGs and serum glucose are important risk factors in the development of BC.

The study aimed to determine the association of dyslipidemia and increased insulin resistance (IR) with increased breast cancer risk. The study group comprised 110 premenopausal and 143 postmenopausal, untreated female BC patients in the age range of 29–72 years. Control group consisted of 117 premenopausal and 141 postmenopausal healthy females in the age range of 23–75. Approximately 8-ml blood samples were drawn to measure various biochemical parameters.

Serum glucose, total cholesterol, triglyceride (TG), and high-density lipoprotein-cholesterol were measured. Very low-density lipoprotein-cholesterol (VLDL-C) and LDL-C were calculated using Friedewald's formula. Serum insulin and serum CA 15-3 were estimated by immune enzymatic assay. IR was assessed using homeostasis model assessment IR index (HOMA-IR).

The results revealed that total cholesterol, TG, LDL, VLDL, serum glucose, serum insulin, HOMA-IR, and serum CA 15-3 were significantly higher in BC patients compared to those in controls. The researchers also found a significant positive correlation between total cholesterol, TG, LDL, serum glucose, serum insulin, HOMA-IR, and serum CA 15-3.

Read more about the study here:;year=2018;volume=9;issue=2;spage=85;epage=91;aulast=Kachhawa