Increased risk of gout is associated with rise in Weight ove
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Researchers aimed to investigate the association between weight change patterns across adulthood and incident gout.

Using data from the National Health and Nutrition Examination Survey (NHANES), individuals were categorized into four weight change patterns:
1) Those who remained obese (stable obese),
2) Those who moved from a non-obese body mass index (BMI) to an obese BMI (gaining),
3) Those who moved from an obese BMI to a non-obese BMI (losing), and
4) Those who remained non-obese (stable non-obese).

Incident gout reflected its occurrence over the 10-year follow-up from the recalled midlife weight measure to the time of this survey. Hazard ratios (HRs) and 95% confidence intervals relating weight change patterns to incident gout over the 10-year follow-up period were calculated using Cox models adjusted for covariates. The hypothetical population attributable fraction (PAF) for the weight change patterns was calculated.

--Among our sample of adults aged 40–74 years at their midlife weight measure (n=11,079), 320 developed gout.

--The highest risk of incident gout was found for participants with the stable obese pattern (HR 1.84) and not for participants who remained stable non-obese during adulthood.

--Moreover, gaining weight was a significant risk factor for incident gout (HR 1.65).

--No significant associations were found between losing weight change patterns and the risk of gout during the study period.

If participants who gained weight had become non-obese during the 10-year follow-up, an estimated 3.2% of observed gout cases could have been averted.

In addition, if the population had maintained a normal BMI, 32.9% cases could have been prevented during the 10 years.

In the end, an increased risk of gout was associated with a rise in weight over adulthood. Throughout adulthood, the preservation of non-obese weight and weight loss is important in adult life for the prevention and care.