Increasing Transplantable Donor Lungs through Ex Vivo Lung P
Cold storage of donor organs following procurement and prior to transplant decreases metabolic demand and consumption of energy and has been the standard method in transplantation for more than 40 years. Severe damage occurs when energy stores are depleted, including increased oxidative stress, inactivation of the sodium pump, cell death, and the release of proinflammatory cytokines. Additionally, following implantation, lungs frequently demonstrate varying degrees of ischemia reperfusion injury (IRI) resulting in postoperative graft dysfunction and complications that have short- and long-term implications. Thus, lung preservation and mitigation of IRI remain two of the main concerns in clinical lung transplantation...