Indolent T-cell lymphoproliferative disease with synchronous
Indolent T-cell lymphoproliferative disease (T-LPD) of gastrointestinal tract is a rare recently described disease that seldom progresses. We report a case of T-LPD with synchronous diffuse large B-cell lymphoma (DLBCL) that cause aggravation of disease.

A 46-year-old Chinese male presented with intermittent paraumbilical colic pain, bloating, and occasional diarrhea for 10 years. His condition aggravated with partial bowel obstruction recently. The patient was diagnosed as T-LPD initially based on histological result and T-cell receptor-gamma clonal gene rearrangement test. The patient was followed without chemotherapy. His condition stabilized for 1 year and then deteriorated with small intestine perforation.

The patient was diagnosed as indolent T-LPD and DLBCL finally. The patient had surgery for intestine perforation and received chemotherapy for DLBCL and T-LPD afterward. At 6 months follow-up, the patient continued to have resolution of his symptoms.

Source: Medicine: April 2019 - Volume 98 - Issue 17 - p e15323

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