Indoor Environment Could Worsen Dry Eye- JAMA Study
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The ocular surface is continuously exposed to the environment. Although studies have focused on associations between outdoor environmental conditions and dry eye, information on associations between the indoor environment and dry eye is lacking.

This study aimed to determine associations between the indoor environment and dry eye. This prospective cross-sectional study sample of 97 veterans with a wide range of dry eye metrics was recruited from the Miami Veterans Affairs Healthcare eye clinic.

Results: Of the 97 participants included in the analysis, 81 (84%) were men, with a mean age of 58.2 (11.9) years. Dry eye symptoms were in the moderate range with a mean (SD) Ocular Surface Disease Index (OSDI) score of 31.2 (23.6). Humidity was associated with worse symptoms and signs, including OSDI score, inflammation, Schirmer score, eyelid vascularity, and meibomian gland dropout.

In multivariate analyses, particulate matter of 2.5 ?m or less (PM2.5) was associated with dry eye metrics when adjusted for demographic characteristics, comorbidities, medications, and interaction variables. For example, a 1-unit increase in instrumented PM2.5 level was associated with a 1.59 increase in the OSDI score, a 0.39 reduction in Schirmer scor, a 0.07 increase in meibomian gland dropout, and a 0.06 increase in inflammation.

Conclusively, When adjusting for humidity, this study found that increased particulate matter exposure was associated with worse dry eye metrics. Humidity was positively associated with dry eye metrics, potentially because higher humidity increases microbial growth and particulate matter size and mass.

Source: https://jamanetwork.com/journals/jamaophthalmology/article-abstract/2767886
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