Induction of labor with oral misoprostol solution versus vag
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Induction of labor is the artificial initiation of labor before the spontaneous onset, and it is the common obstetric intervention. Oral misoprostol shows a shorter induction delivery interval compared to vaginal misoprostol.

The objective of this study by the Indian Journal of Obstetrics and Gynecology Research was to compare the potency of oral misoprostol solution with vaginal misoprostol to induce labor at term.

80 women requiring induction were recruited in the study. The women were randomized to receive 20 micrograms of oral misoprostol solution every 2nd hourly or vaginally 25 micrograms of misoprostol every 6th hourly until the labor sets in the active phase of labor. Delivery within 24 hours was the outcome of the study.

--82.5% of women in the oral group delivered by spontaneous vaginal delivery, whereas 75% in the vaginal group.

--In the oral group, 37.5% of delivery occurred within 6-12 hours, 40% delivered within 12-18 hours duration, whereas in the vaginal group, 12.5% delivered within the 6-12hours duration, 50% delivered within 12-18 hours duration.

--Oxytocin augmentation was required in 25% of the oral group, whereas 42.5% in the vaginal group.

--Meconium-stained liquor was 12.5% in the oral group, whereas 20% in the vaginal group.12.5% underwent cesarean section in the oral group, 10% in the vaginal group.

Conclusively, compared with vaginal misoprostol, oral misoprostol solution results in shorter induction delivery interval and less oxytocin augmentation required.

Source: https://doi.org/10.18231/j.ijogr.2021.019
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