Inflammatory Bowel Disease in a Child with Sickle Cell Anemi
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Homozygous sickle cell anemia (SCA) is an autosomal recessive chronic haemoglobinopathy characterized by abnormal globin chain of hemoglobin (Hb) content of the red blood cells that result in “sickle” shapes, attraction of RBCs to each other, and polymerization when in a low oxygen environment. The RBC polymerization leads to manifestations such as chronic occlusion of blood vessels (vasoocclusion), reduced blood flow to vital organs (ischemia), and alterations of the immune system. The gastrointestinal manifestation of SCA varies . We are reporting a child with SCA who presented with chronic colitis resembling inflammatory bowel disease....

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100385/
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