Influence of Skin Subjective Symptoms on Sleep Quality in Pa
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In patients with cutaneous disorders (CD), previous studies showed more sleep disturbance (SD). Unpleasant subjective symptoms [USS], such as itching, discomfort and others (tingling, burning or tightness) have a detrimental effect on the quality of sleep during CD. The purpose of this study is to assess the prevalence of sleep disturbance in patients with CD and to identify the effect on sleep disturbance of itching, pain and other unpleasant sensations.

An international, anonymized real-life survey was conducted with individuals [18-75 years], with physician-confirmed CD, or without CD. The 25 items covered sociodemographic characteristics, feeling of overall sleep quality and skin unpleasant sensations. Severity of SD and unpleasant sensations were assessed using a 10-cm Visual Analogue Scale (VAS).

--From 3834 analyzed questionnaires, 2871 were in the CD group and 863 in the control group.

--Patients with CD had significantly more SD (71.2% vs 32.7% in the control group).

--CD patients without any reported unpleasant sensation were at higher risk for SD than control subjects (OR 1,362).

--SS were highly associated with SD (OR 1.641). Pruritus, pain and intermediate sensations were significant predictors of SD, with odds ratios of 1.670, 1.625 and 1.326, respectively.

--VAS sleep scores were strongly associated with pruritus (r: 0.25) and pain (r: 0.25) severity ratings.

Sleep disturbance is a prevalent issue for CD patients. In CD patients, patients with subjective symptoms suffer more from SD, implying that these are aggravating factors, but are certainly not the only cause for sleep disturbance. It was observed that intermediate sensations also lead to sleep disturbance during CD.