Influence of Various Osmogens on Drug Release from Immediate
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Tramadol HCl is a centrally acting analgesic having amino cyclo hexanol group, which has a strong analgesic action. It is administered when non-steroidal anti-inflammatory drugs fail to mitigate pain.Conventional sustained release formulation of Tramadol hydrochloride is not adequate because of lack of initial bolus dose. This drawback can be overcome by formulating immediate release tablet. Immediate release technology is to achieve improved bioavailability, rapid onset of action, chemical stability and patient convenience and compliance. The objective of present investigation was to explore application of osmogens as disintegrant and to study the influence of various osmogens on drug release....

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