Insufficient screening for heart damage after noncardiac sur
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About five percent of patients experience heart muscle injury around the time of their surgery for a noncardiac condition, yet guideline recommendations to identify patients at risk using biomarkers are not being followed. A five-year study in Alberta, Canada appearing in the Canadian Journal of Cardiology, determined that the recommended biomarker screening is very much underutilized.

Of the 1.5 million Canadians who undergo inpatient noncardiac surgery each year, 22,000-45,000 will experience a perioperative cardiac event. For this reason, guidelines now recommend that patients with risk factors for heart disease have cardiac enzyme measurements done after their surgery, even if they do not have any symptoms.

"Although surgical and anesthetic advancements and more effective treatments for heart damage have resulted in fewer people dying around the time of surgery, perioperative cardiovascular complications remain an important concern," explained lead investigator.

Without biomarker screening, asymptomatic cardiac events may not be picked up for prompt treatment, which could lead to complications and excess deaths. "Many of these events are silent, meaning that patients will not experience any chest pain alerting their doctors that they are experiencing heart damage. For most of these patients, the only way that we would identify this is by measuring cardiac enzymes in their blood released by damaged heart cells," he added.

Evidence of the utility of biomarkers for perioperative screening began to emerge following the results of the 2011 Perioperative Ischemic Evaluation (POISE) study. In response to this growing evidence, multiple national and international guidelines for noncardiac surgery now recommend perioperative cardiac biomarker screening in high-risk patients.

Using linked provincial administrative databases, investigators looked at the records of more than 300,000 patients in Alberta who had undergone noncardiac surgery from January 2013 to December 2017. They found that roughly one in five surgical patients, or 59,506, had risk factors for heart disease. Of these higher risk patients, only around seven percent underwent preoperative screening for the natriuretic peptide biomarker. Natriuretic peptides, which were originally used to diagnosis heart failure, now play an increasing role in identifying patients most at risk of cardiovascular disorders.

Patients with elevated perioperative screening biomarkers demonstrated increased six-month mortality, increased hospitalizations for heart failure, and acute coronary syndromes.

Investigators concluded that the use of biomarkers to assist in cardiac risk stratification and postoperative monitoring remains low, and they recommend addressing access to these tests and improving physician education regarding the asymptomatic nature of postoperative cardiac events to improve compliance with national guidelines.

Source: https://www.onlinecjc.ca/article/S0828-282X(20)30521-3/fulltext
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