Intensive Reduction Of Systolic BP Associated With Decreased
A randomised control trial assigned 9361 participants into two treatment groups; the intensive treatment target group and standard treatment target group. Results showed that at a median of 3.33 years of follow-up, the rate of the primary outcome and all-cause mortality during the trial were significantly lower in the intensive-treatment group than in the standard-treatment group. Serious adverse events of hypotension, electrolyte abnormalities, acute kidney injury or failure, and syncope were significantly more frequent in the intensive-treatment group. When trial and post-trial follow-up data were combined, similar patterns were found for treatment benefit and adverse events. Study revealed that among patients who were at increased cardiovascular risk, targeting a systolic blood pressure of less than 120 mm Hg resulted in lower rates of major adverse cardiovascular events and lower all-cause mortality than targeting a systolic blood pressure of less than 140 mm Hg, both during receipt of the randomly assigned therapy and after the trial.

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https://www.nejm.org/doi/full/10.1056/NEJMoa1901281
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