Intestinal Metaplasia of the Urinary Bladder: is Smoking a R
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"Cystitis glandularis is relatively a common appearance in the urinary bladder; it results from the metaplasia of the urothelium due to chronic irritation into intestinal epithelium.
Case Presentation: A 49 year- old gentleman, who is hypertensive and has history of heavy smoking for the last 30 years, presented to Urology clinic with terminal hematuria, suprapubic pain for 4 years, and irritative voiding symptoms for 8 months. Apart from normal clinical exam, radiology images showed a polypoid bladder mass after which he underwent TURBT.By literature review it has been suggested that chronic irritation is the main causative factor; cystitis, stones, bladder exstrophy, ureteral reimplantation, and prolonged instrumentation have been implicated as factors of irritation. However, smoking hasn't been related as a cause of such disease."....

http://medcraveonline.com/UNOAJ/UNOAJ-04-00150.php
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