Intracanalicular Dexamethasone Ophthalmic Insert for the Tre
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Patients who had bilateral RLE preffered intracanalicular inserts over topical steroids for post-operative steroid treatment. A Study was conducted to determine patient preference and treatment outcomes with an intracanalicular dexamethasone (0.4 mg) insert compared to standard steroid drop regimen in the contralateral eye following bilateral RLE surgery.

This study includes 20 individuals who received bilateral RLE. Each patient served as their own control, with one eye receiving an intracanalicular insert (Group A) at the time of surgery and the other receiving topical corticosteroid drops (Group B). At the time of surgery, all eyes received intracameral moxifloxacin, as well as topical moxifloxacin QID for one week and topical NSAID daily for four weeks. On Day 1, Week 1, and Weeks 4–8, post-operative evaluations were completed.

Results:
--At 4– 8 weeks post-operation, 90% of patients evaluated with the COMTOL questionnaire preferred the intracanalicular insert while 10% preferred the topical steroid.

--Comparative analysis using the visual analog scale showed no difference in pain between the study and control group.

--No statistical difference was shown in post-operative corneal staining, anterior chamber cell count, anterior chamber flare or intraocular pressure.

--Mean LogMAR UCVA at 4– 8 weeks post-operation was 0.06 in the study group and 0.065 in the control group, which was not statistically or clinically different.

Finally, patients who had bilateral RLE reported a substantial preference for intracanalicular inserts over topical steroids for post-operative steroid treatment. In terms of cystoid macular edema, visual acuity, and intraocular pressure rise, there was no clinically or statistically significant difference in results.

Source: https://www.dovepress.com/a-randomized-controlled-prospective-study-of-the-effectiveness-and-saf-peer-reviewed-fulltext-article-OPTH
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