Intraglandular botulinum toxin injections for treatment of s
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Botulinum toxin type A (BoNTA) injections are efficacious for the treatment of sialadenosis but they're partially effective in improving parotidomegaly and often require repeated injections.

Researchers aimed to evaluate the safety and efficacy of botulinum toxin type A (BoNTA) injections for the treatment of sialadenosis. The study was published by Clinical Otolaryngology.

Investigators retrospectively reviewed 20 patients treated with intraglandular BoNTA injections. Patient satisfaction was assessed using Likert scales: a three?point scale to evaluate improvement in the sense of parotid distention and a five?point scale to assess improvement in cosmesis. Complications, such as salivary dysfunction and facial weakness, were monitored during follow?up after injections.

Patients received a median of two injections of BoNTA (40–50 U/mL per injection) into each parotid gland.

--Three months after treatment, 5, 11, and 4 patients experienced complete, partial, and no relief of salivary gland distention with discomfort, respectively.

--For esthetic scoring, 2, 5, 10,3, and no patients were assigned scores of 3, 2, 1, 0, and ?1, respectively.

--Salivary gland scintigraphy was performed for 14 patients before injection. Ten and four patients showed normal and increased uptake by the salivary glands, respectively.

-- At 3 months after injection, salivary gland scintigraphy showed that maximum salivary secretions significantly decreased, whereas salivary flow did not significantly differ between pre-and post?injection.

--No patient complained of dry mouth or facial weakness during follow?up.

Overall, intraglandular BoNTA injections might be an alternative option for treating symptomatic sialadenosis, although it is only partially effective for alleviating parotidomegaly and often requires repeated injections.