Intranasal Covid-19 Vaccine Phase-1 Trial Commence In Hydera
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Phase 1 of the clinical trial of Bharat Biotech’s nasal Covid-19 vaccine candidate began at a hospital in Hyderabad on March 5. The clinical trial for Bharat Biotech’s nasal Covid-19 vaccine candidate has been kicked off in Hyderabad.

Both the patients who have received the dose are healthy and doing fine after receiving the vaccine. Bharat Biotech was given the permission to conduct the first phase of a clinical trial for its intranasal Covid-19 vaccine BBV154 by the Drugs Controller General of India (DCGI) on March 2.

The intranasal vaccine is different from the intramuscular vaccines that were recently approved by the Indian drug regulator for restricted emergency use in the country. Krishna Ella, Chairperson of Bharat Biotech, had earlier said the company is focusing on the intranasal vaccine as existing vaccines require two-dose intramuscular injections.

An intranasal vaccine will not only be simple to administer but reduce the use of medical consumables such as needles, syringes, etc. This is likely to significantly impact the overall cost of vaccination drive, he had said. As per the company, what makes the nasal stand apart from other candidates is that it’s built on a flu vaccine backbone that has already been shown to be safe and well-tolerated in humans, in Phase I and Phase II clinical trials.

Bharat Biotech is developing the nasal vaccine in an international collaboration with virologists of the University of WisconsinMadison and vaccine company FluGen. "The vaccine will build on the backbone of FluGen's flu vaccine candidate known as M2SR. Researchers will insert gene sequences from SARS-CoV-2, into M2SR so that the new vaccine will also induce immunity against the coronavirus," Bharat Biotech said.

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