Intraoperative rupture of the Ovarian Capsule in Early-Stage
Intraoperative ovarian capsule rupture has a negative effect on progression-free survival and overall survival in women who are undergoing surgery for early-stage ovarian cancer.

High-quality studies reporting survival outcomes comparing ovarian capsule rupture to no capsule rupture among patients with early-stage epithelial ovarian cancer who underwent surgical management were abstracted.

Seventeen studies met all the criteria for inclusion in the meta-analysis. Twelve thousand seven hundred fifty-six patients did not have capsule rupture and had disease confined to the ovary on final pathology; 5,532 patients had intraoperative capsule rupture of an otherwise early-stage ovarian cancer.

- Patients with intraoperative capsule rupture had worse progression-free survival, with moderate heterogeneity when compared with those without capsule rupture.

- Pooled results from these studies showed a worse overall survival, with moderate heterogeneity when compared with patients without intraoperative capsule rupture. This remained significant in a series of sensitivity analyses.

This systematic review and meta-analysis of high-quality observational studies show that intraoperative ovarian capsule rupture results in decreased progression-free survival and overall survival in women with early-stage ovarian cancer who are undergoing initial surgical management.

Obstetrics & Gynecology
Source: https://journals.lww.com/greenjournal/Abstract/2021/08000/Intraoperative_Rupture_of_the_Ovarian_Capsule_in.13.aspx
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