Intraretinal Hyperreflective Lines: A Quick Review
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To report intraretinal hyperreflective lines related to various macular conditions a study was conducted. Forty-nine eyes of 43 patients (16 men and 27 women) were included. Hyperreflective vertical lines (38 eyes) or curvilinear lines along the Henle fiber layer (11 eyes) were present in association with various macular conditions: adult vitelliform dystrophy or pattern dystrophy (24 eyes) frequently associated with an epiretinal membrane (six eyes) and/or thick choroid (nine eyes), age-related maculopathy or macular degeneration (nine eyes), partial resorption of subretinal or intraretinal hemorrhages (five eyes), idiopathic macular microhole (two eyes), vitreomacular traction (three eyes), multiple evanescent white dot syndrome (three eyes), fundus flavimaculatus (two eyes), and pachychoroid pigment epitheliopathy (one eye).

The lines fully vanished in cases of hemorrhages, multiple evanescent white dot syndrome, or the resolution of vitreomacular traction, but usually persisted with gradual thinning in the other conditions. The present series showed that intraretinal hyperreflective lines could occur in various inflammatory, degenerative, or tractional conditions. They could reflect a previously unrecognized reaction to the various photoreceptors, Müller cells, and/or retinal pigment epithelium damage.

Source:https://journals.lww.com/retinajournal/Abstract/2021/01000/INTRARETINAL_HYPERREFLECTIVE_LINES.10.aspx
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