Intrauterine Vertical Transplacental Transmission Of COVID-1
Get authentic, real-time news that helps you fight COVID-19 better.
Install PlexusMD App for doctors. It's free.
A 27-year-old woman (gravida 2, para 1) was transported to the regional university hospital in gestational week (GW) 34+4 due to a 3-day history of fever, abdominal pain and reduced fetal movements. She had developed a dry cough 1 day prior to the admission. The woman, was slightly overweight but otherwise healthy.

At admission, the patient was promptly isolated in a negative pressure room at the delivery unit and standard operating procedures and personal protective equipment (PPE) were used. A combined nasopharynx (NPH) throat swab for SARS-CoV-2 using RT qPCR was obtained and normal vital parameters (apart from 38.3°C fever) were registered.

The admission cardiotocograph (CTG) test showed reduced baseline variability, absence of accelerations with recurrent prolonged, and late decelerations. In light of the pathological CTG pattern, the obstetric team made the prompt decision to deliver the patient by an immediate caesarean section (CS). An uncomplicated CS was performed in an operating theatre with negative pressure, in line with the international recommendations for COVID-19.

The neonate showed no initial signs of spontaneous breathing and was ventilated by neonatal staff in a separate room. A maximum of 80% supplemental oxygen was needed to maintain adequate saturation. At 6 minutes of age, the neonate established spontaneous breathing and continuous positive airway pressure was maintained for an additional 24 minutes, whereafter further ventilatory support was not needed.

At 1 minute of age, the neonate had an Apgar score of 1, at 5 minutes of age Apgar 4, and at 10 minutes of age Apgar 8. Validated umbilical cord blood gases showed a cord arterial pH of 7.20 and a venous pH of 7.22. Cord arterial lactate was 11 mmol/l and cord venous lactate 10.1 mmol/l.

After the CS, the mother was isolated in the postpartum ward; the NPH/throat swab taken upon admission returned positive for SARS-CoV-2. Analysis of maternal blood was also RT qPCR-positive for SARS-CoV-2. Serology from the day of delivery revealed that the mother was weakly positive for immunoglobulin (Ig) M and negative for IgG. The clinical condition of the mother improved and she was discharged 4 days after delivery.

Thromboprophylaxis was prescribed for 6 weeks postpartum in accordance with national guidelines in place at the time. By day 11 postpartum, the mother was seropositive for antiSARS-CoV-2 IgM and IgG. Breast milk analysed day 14 postpartum was RT qPCR-negative for SARS-CoV-2 and, further, at day 35 postpartum, the breast milk was negative for anti-SARSCoV-2 total immunoglobulin.

The neonate in this case had no contact with any family member, including the mother, for the first 60 hours of life. As neither skin-to-skin care nor any other contact with the mother occurred, the neonate was regarded as non-infected. In accordance with national guidelines at the time, the neonate was tested for COVID-19 using a NPH swab 48 hours after delivery. This test returned positive for SARS-CoV-2 and the neonate was then regarded as contagious.

The neonate was transferred and united with the mother in the postpartum ward isolation room at day of life (DOL) 3 (60 hours after birth). Breastfeeding was thereafter initiated and the neonate did not receive any breastmilk before this time point. Repeated RT qPCR analyses showed the lowest neonatal CT-value at DOL 5, whereafter a gradual increase was seen. By DOL 20, SARS-CoV-2 was not detectable in NPH or throat swabs.

Serology revealed that the neonate was anti-SARS-CoV-2 IgG-negative at DOL 7 (IgM not analysed due to lack of material). At DOL 14, IgM was positive and IgG still negative, and at DOL 20, the neonate was both IgM- and IgGseropositive. Given these genetic findings and the series of events presented above, along with the marked placental pathology and the high viral load, it can be concluded that the neonate was infected in utero.

Two main clinical lessons can be learnt from the current case:

~ Intrauterine vertical transmission is an uncommon complication of COVID-19 during pregnancy which may lead to placental dysfunction.
~ Clinical consequences for the newborn intrauterine SARS-CoV-2 transmission may not necessarily lead to severe neonatal outcome.

Source:
https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/1471-0528.16682
Like
Comment
Share