Intravitreal Conbercept for Diabetic Macular oedema found to
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
A Study was conducted to demonstrate the efficacy and safety of intravitreal injections of Conbercept versus laser photocoagulation in the treatment of diabetic macular oedema (DME).

Patients with centre-involved DME were randomly assigned to receive either laser photocoagulation followed by pro re nata (PRN) sham intravitreal injections (laser/sham) or sham laser photocoagulation followed by PRN 0.5 mg conbercept intravitreal injections (sham/conbercept). Patients who entered the extension study received PRN conbercept treatment. The primary endpoint was the changes in best-corrected visual acuity (BCVA) from baseline.

Results:
--A total of 248 eyes were included in the full analysis set and 157 eyes continued in the extension study.

--Significant improvement in mean change in BCVA from baseline to month 12 was observed in the sham/conbercept group, whereas no improvement was observed in the laser/sham group (0.3±12.0 letters).

--Patients in the laser/sham group showed a marked improvement in BCVA after the switch to conbercept in the extension study, and there was no difference in BCVA between the two groups at the end of the extension study.

Finally, the use of a conbercept PRN intravitreal injection regimen enhanced the BCVA of patients with DME, and its efficacy was superior to laser photocoagulation. The same efficacy was observed when the eyes treated with laser alone were moved to conbercept.

Source: https://bjo.bmj.com/content/early/2021/05/16/bjophthalmol-2020-318690?rss=1
Like
Comment
Share