Irrespective of Platelet-Rich Plasma, Intra Articular Inject
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A Study was conducted to compare a single abdominal microfat (MF) injection mixed or not with Platelet-Rich Plasma (PRP) Low Dose (LD) or High Dose (HD) in order to improve MRI parameters and alleviate pain and enhance functional capacity in knee osteoarthritis (OA).

Patients with symptomatic grade 2 to 4 knee OA were selected. They were prospectively assessed at baseline, at 3 and 6 months of follow-up. The primary endpoint was the change in maximum of value of cartilage relaxation time in T2 mapping sequences (T2max) at 3 months. The complete cell counts and growth factors content of injected products were assessed to analyze their potential relationship with MRI/clinical outcomes.

Results:
--Three groups of 10 patients received a single injection of 10 cc of a mix (1:1) containing either MF-Saline, MF-PRP LD or MF-PRP HD.

--T2max did not change significantly over the time for any of the groups. All treatments significantly improved knee functional status and symptoms relief at 3 and 6 months.

--All patients were responders in the MF/PRP HD at 3 months and significantly higher compared to MF/PRP LD.

--Half of the injected PRP in the MF/PRP LD group displayed RBCs contamination over 8% which was correlated with an impairment of T2max.

To summarize, a single intra-articular injection of MF with or without PRP is safe and can provide substantial clinical improvement in OA patients.

Source: https://www.arthroscopyjournal.org/article/S0749-8063(21)00340-6/fulltext
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