Is High-Dose Vitamin D Harmful in Women?- Finds a New Study
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High-dose vitamin D supplementation may have harmful effects on postmenopausal women, a post-hoc analysis of randomized clinical trial data suggested.

Over a 3-year period, women who received 400 IU of vitamin D daily had a -1.8% loss in total bone mineral density (BMD) at the radius, reported researchers.

In contrast, those given 4,000 IU per day had a -3.8% loss in total BMD at the radius, and those receiving 10,000 IU per day had a -5.5% loss, which was statistically significant, said researchers during the virtual American Society for Bone and Mineral Research meeting.

A total of 303 individuals were included. Their average age was 62, 53% were men, and mean BMI was 28. Total hip BMD scores ranged from -0.5 to 0.7, and mean level of 25(OH)D was 78 nmol/L, which indicated vitamin D sufficiency.

The radius and tibia were scanned on high-resolution peripheral quantitative CT to measure total volumetric BMD at baseline and at 6, 12, 24, and 36 months. In addition, fasting C-telopeptide of type 1 collagen (CTx) and amino-terminal propeptide of type 1 collagen (P1NP) were assessed.

Unlike for women, who had a clear dose response, no significant bone loss or difference according to dose at month 36 at the radius was observed for men, with losses of -0.9%, -1.3%, and -1.9% for 400 mg, 4,000 mg, and 10,000 mg/day, respectively.

Similar results were observed at the tibia, though at a smaller magnitude, with women again having a significant dose response relationship. Among women given 400 mg/day, the change at 3 years was -1%, while among those receiving 4,000 or 10,000 mg/day, changes were -2% and -3.2%. For men, again there was no difference, with changes of -0.1%, 0%, and -0.6%, respectively.

Additional findings included a trend for women in the 10,000 IU group to have higher CTx values than those in the 400 mg group as well as a trend for women to have slightly higher P1NP values.

"These results support those of the recent VITAL trial, finding no detectable effect of vitamin D supplementation and sex effects, although the VITAL trial did report a trend for smaller decreases in areal BMD at the spine in women," researchers said.

Source: https://asbmr.onlinelibrary.wiley.com/doi/abs/10.1002/jbmr.4152
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C●●●●●●l S●●i General Medicine
So finally how much Vit D should one take??
Sep 13, 2020Like1