Is Saturated Fat or Carbohydrates Worse for the Liver?
Are saturated fats (SFAs) or polyunsaturated fats (PUFAs) more likely to cause fat deposits in the liver? What is worse for the liver — overfeeding of SFAs or sugar (simple carbohydrates)?

Fat that accumulates in the liver is known as ectopic fat. And we know that excessive accumulation of both subcutaneous and ectopic or visceral fat distribution causes a chronic state of inflammation and can lead to obesity, which creates a greater risk for type 2 diabetes and cardiovascular disease. Accumulation of visceral and ectopic fat is associated with a higher risk for other diseases than is subcutaneous fat.

The high-fat and high-carbohydrate diets seen in obesity predispose to lipotoxicity and glucotoxicity and play a significant role in development of steatosis and progression to NASH. Release of FFAs from insulin-resistant adipocytes activates inflammatory pathways. This reduces hepatocyte capacity to dispose of excess FFAs, which leads to lipoapoptosis, a feature of NASH.