Isolated xanthogranuloma of pelvico-ureteric junction: is th
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Xanthogranulomatous Pyelonephritis (XGP) is a rare condition characterised by chronic granulomatous inflammation of renal tissue. This can be due to obstruction, urinary tract infection and renal calculi. The exact pathophysiology and progression of this condition is poorly understood, but altered immune response, changes in lipid metabolism, disturbances in leukocyte function, lymphatic obstruction, venous occlusion/haemorrhage, malnutrition, arterial insufficiency and necrosis of pericalyceal fat. Its management with surgical intervention in the form of nephrectomy, partial or complete, is the most definitive management option of this condition. We report the case of a woman with isolated xanthogranuloma obstructing the pelviureteric junction. We propose this as the initial pathophysiological process of Xanthogranuloma pyelonephritis...

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