Just another chalazion? #OneMinuteOphthalmology
The present case has been reported in the Indian Journal of Ophthalmology.

A 60-year-old male noted a red lesion on the right lower eyelid which was growing over 3 months. He revealed previously treated cancers of the colon, ureter, and skin, all under control without recurrence. He also noted previous eyelid surgery 2 years ago revealing a well-differentiated sebaceous carcinoma.

Family history disclosed multiple members with skin and colon carcinomas. On examination of the patient, visual acuity was 20/20 OD and 20/30 OS. There was an elevated, lightly colored cutaneous lesion on the right lower eyelid margin, temporal to the site of the previous biopsy and measuring 6 × 4 × 3 mm.

A pentagonal eyelid resection of the mass was performed. Histopathology revealed a low-grade sebaceous neoplasm most consistent with sebaceous adenoma.

Immunohistochemical testing for DNA mismatch repair proteins in the excised tissue demonstrated normal staining for MLH1 and abnormal absence (lack of staining, mutation) for MSH2. These findings were suggestive of underlying Muir-Torre syndrome (MTS).

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