Just as the heart is the focal organ in the circulatory system snd the brain is the hub of integrative activity the liver is the center for metabolism in the body. The synthesis modification storage breakdown and excretion of many of the substances upon which life depends occur in the liver.The functions of the liver exceed those of all other organs in number and complexity. The liver is the primary center for the synthesis of most of the proteins involved in blood coagulation. It manufactures fibrinogen prothrombin and factors V VII VIII IX XI And XII. Vitamin K is required for the formation of prothrombin and factors VII IX And X.