Kayser-Fleischer-like rings in patients with hepatic disease
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
The Kayser-Fleischer (KF) ring is an ophthalmic finding seen secondary to systemic disease that causes dysfunction in copper metabolism. It is defined as a pigmented ring due to copper deposition in Descemet’s membrane. It is seen at the sclerocorneal junction mostly as golden brown/greenish-yellow in color. Though The Kayser-Fleischer ring is pathognomonic of Wilsons disease, it is also seen in various other hepatic conditions. Detection of KF rings in asymptomatic cases can help in clinching early diagnosis and starting early treatment. The Kayser-Fleischer ring is correlated with disease severity, disappears on treatment, and reappears on discontinuation of the treatment. The Kayser-Fleischer ring is initially evident at superior and then inferior corneal poles and becomes circumferential later. It begins as a sharp line where the endothelial pattern is seen distinctly (Schwalbe’s line). It rarely extends more than 5 mm centrally and starts fading towards the central cornea. The clear corneal ring seen around the Kayser-Fleischer ring depends upon the position of Schwalbe’s line.

The aim of this work was to study Kayser-Fleischer [KF]-like rings in patients with hepatic or cholestatic liver disease and to find out the relation between serum bilirubin level and the presence of Kayser-Fleischer like a ring in these patients.

In this study, researchers evaluated patients with hepatic and cholestatic liver diseases with total Serum bilirubin levels >10 mg/dl. These patients were evaluated for the presence or absence of Kayser-Fleischer-like rings.

A total of 67 patients with a total bilirubin of more than 10 mg/dl were included in the study. Patients were divided into 3 groups based on total S. bilirubin level: Group 1 with S. bilirubin more than 30 mg/dl, Group 2 with S. bilirubin more than 20 - less than 30 mg/dl, and Group 3 with S. bilirubin more than 10 - less than 20 mg/dl at baseline evaluation. On follow-up, they were divided into 3 groups based on the serum bilirubin level. Group 1- more than 20 mg/dl, Group 2- more than 10 - less than 20 mg/dl, Group 3- less than 10 mg/dl. Kayser-Fleischer like the ring was seen in 98.5% of patients with high total S. bilirubin levels. Kayser-Fleischer-like ring disappeared in 87.5% of patients with a reduction in the total S. bilirubin level to less than 10 mg/dl.

Kayser-Fleischer like the ring was seen in 98.5% of patients with high total S. bilirubin, disappeared in 87.5% of patients with a reduction in the total S. bilirubin level to less than 10 mg/dl. There was no significant difference between the Total S. bilirubin levels, age, gender, and Kayser-Fleischer Like Ring.

Source:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186623/
Like
Comment
Share