Keratoplasty Outcomes in Patients With Uveitis, finds Study
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A Study was conducted to examine the corneal transplant failure rates and associations with uveitic eye disease.

The retrospective chart review identified 70 eyes from 42 patients with uveitis that underwent 40 primary transplants and 30 repeat transplants at 2 major academic centers over a 9-year period. The graft failure rate was calculated. Variables hypothesized to be associated with graft failure were analyzed as covariates using a Cox proportional hazards analysis clustered by the patients to determine their association with failure rates.

Results:
--Of the 70 grafts, the mean duration of follow-up for patients was 40.6 months and the median survival time was 24.1 months.

--22 patients had graft failure. There was a higher rate of graft failure in patients with infectious uveitis as compared to those with noninfectious uveitis (hazard ratio 2.46).

--Patients with successful grafts had their inflammation controlled for a longer period of time before transplantation as compared to those with failed grafts (38.6 vs. 13.6 months).

--Worse preoperative visual acuities were significantly associated with graft failure.

In conclusion, over half of the grafts in this study failed. The presence of infectious uveitis (especially viral uveitis) was found to be a strong predictor of graft failure. Graft failure was also linked to a shorter duration of inflammation control before transplantation, previously failed grafts, and poor preoperative visual acuity.

Source: https://journals.lww.com/corneajrnl/Abstract/2021/05000/Keratoplasty_Outcomes_in_Patients_With_Uveitis.8.aspx
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